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Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

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From a clinical standpoint, they demonstrated that linezolid had better efficacy than vancomycin for the treatment of MRSA NP (on the basis of trial data specifically in MRSA-confirmed patients), with fewer patients requiring a switch to second-line therapy.

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AHA recommends that patients with infective endocarditis attributable to enterococci resistant to penicillins, aminoglycosides, and vancomycin be managed by a team of specialists in infectious disease, cardiology, cardiovascular surgery, clinical pharmacy, and, if necessary, pediatrics.

TRAMADOL products in excessive doses, either alone or in combination with other CNS depressants, including alcohol, are a cause of drug-related deaths.

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